Metaflammation and Vaccines

Emerging theories

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Fig.: Inflammation vs Metaflammation [Credit: InfoHealer]

Concept of Metaflammation

Metaflammation is a portmanteau of metabolism and inflammation. It is defined as a chronic low-grade inflammatory state induced by alterations in metabolism. This concept is relatively novel and it is still rather poorly understood. Recent advances have identified key mediators and pathways that link altered metabolism and chronic inflammation with target organ injury. PubMed first recorded use of the term metaflammation in 2008. More recently, it was defined as a chronic low-grade inflammatory state induced by alterations in metabolism.

Metaflamation occurs in conditions associated with metabolic dysfunction, such as obesity and insulin resistance. It can be induced also by early stages of viral infection and by certain medication, hence, possibly also by vaccines. While it is sometimes referred to as a low-grade inflammatory state, it differs si…